Development of a new generation of neurovascular device for the treatment of cerebral bifurcation aneurysms

Abstract

Cerebral (brain) aneurysm (CA), is an abnormal dilation of the cerebral arterial wall, which accounts for more than half a million deaths each year worldwide. It is well recognized that hemodynamic factors play an important role in aneurysm development and propagation. Flow diverters (FDs) represent one method recently developed in treating CAs .

Evasc Medical System Inc., whose area of expertise is developing novel CA therapies, has recently introduced a novel FD (eCLIPs) for the percutaneous treatment of bifurcation cerebral aneurysms. Unlike other devices for such treatment, eCLIPs is implanted at the daughter arteries and does not impede the flow in the main or daughter arteries. Prior studies in the literature clearly indicate the advantages of eCLIPs over conventional FDs, such as Pipeline (Medtronic product), in disrupting the flow at the aneurysm neck. In spite of its advantages over other FDs in the market, there are some shortcomings pertaining to eCLIPs design, including blood flow leakage through the gap between the device and parent artery where there is a fusiform-like pathology.

In partnership with Evasc, we have developed a new design for eCLIPs for particular aneurysms that have fusiform-like properties involving the confluence of the main and daughter branches.