End-to-End Pipeline for Fourier Domain Optical Coherence Tomography of Human Optic Nerve Head

Abstract

Glaucoma is an ocular neurodegenerative disease which causes progressive, irreversible loss of vision. Elevated intraocular pressure is a major risk factor; however, the significant variance among individual susceptibility has not been fully understood. In recent studies, biomechanical changes in Optic Nerve Head (ONH) structures have been identified as a fundamental determinant in the development and progression of the disease. This report presents an end-to-end pipeline of three-dimensional Optical Coherence Tomography (OCT) imaging and analysis, developed to non-invasively visualize and perform comprehensive morphometric analysis of the ONH structures in humans. In particular, correction of subject motion artifact in volumetric ONH images is discussed in detail.