Overall and Dynamic Elasticity Study of Endothelial Cell by Atomic Force Microscopy

Authors

  • Qiuquan Guo University of Western Ontario
  • Y. Liu University of Western Ontario
  • Y. Xia University of Western Ontario
  • M. Sandig University of Western Ontario
  • J. Yang University of Western Ontario

Abstract

Biomechanical property of cells has been recognized to be related to many biological functions. The mechanical performance of endothelial cell is highly heterogeneous in both space and time. In this study, atomic force microscopy (AFM) was used as a nanosensor to measure the elasticity of a single cell. Given the heterogeneous and complex nature of cell mechanics, the overall elasticity of human aortic endothelial cell (HAEC) is measured in this study. In addition, the dynamic elasticity property of HAEC is also examined. Cells show increase in elasticity as scanning time increases.

Author Biographies

Qiuquan Guo, University of Western Ontario

Biomedical Engineering

Y. Liu, University of Western Ontario

Mechanical & Materials Engineering

Y. Xia, University of Western Ontario

Department of Anatomy & Cell Biology

M. Sandig, University of Western Ontario

Department of Anatomy & Cell Biology

J. Yang, University of Western Ontario

Biomedical Engineering,

Mechanical & Materials Engineering

 

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Published

2010-06-15

How to Cite

[1]
Q. Guo, Y. Liu, Y. Xia, M. Sandig, and J. Yang, “Overall and Dynamic Elasticity Study of Endothelial Cell by Atomic Force Microscopy”, CMBES Proc., vol. 33, no. 1, Jun. 2010.

Issue

Vol. 33 (2010)

Section

Academic