Advanced Glycation End Products in Patients with Leukoaraiosis

Authors

  • Feng Yu Ahui Medical University, Anhui Province Hospital
  • Gong Zhang University of Winnipeg
  • Francis Lin University of Manitoba
  • Yong Liu Chinese Academy of Sciences
  • Jian Ren University of Winnipeg
  • Yikun Wang Chinese Academy of Sciences
  • Kai Wang Anhui Medical University, Anhui Province Hospital

Abstract

Objective: To investigate the relationship between leukoaraiosis and Advanced glycation end products (AGEs).

Background: Accumulation of AGEs in the skin, serum, and other specimens obtained from diabetic patients has been linked to the progression of microvascular complications. Moreover, tissue accumulation of the AGEs can be measured by skin autofluorescence.

Methods: 220 healthy Chinese adults were studied. The screening system included medical and neurological examination, head MRI scans, and blood tests. Leukoaraiosis was diagnosed with T1-weighted, T2weighted, and FLAIR images of MRI. 49 cases were leukoaraiosis without diabetes mellitus; 52 cases were leukoaraiosis with diabetes mellitus. Results: Skin AGE levels in patients with leukoaraiosis and diabetes mellitus were significantly increased compared with the control group (2.11±0.12, 2.17±0.176, 2.07±0.129 and 1.918±0.127, respectively, p<0.01). However, there was no significant difference in AGEs between the leukoaraiosis and the diabetes mellitus control. Conclusions: The measurement of skin autofluorescence is a non-invasive and convenient method for AGEs assessment. The result of this study suggested that AGEs can be one of the biomarkers for predicting leukoaraiosis.

Author Biographies

Feng Yu, Ahui Medical University, Anhui Province Hospital

Department of Neurology

Gong Zhang, University of Winnipeg

Department of Applied Computer Science

Francis Lin, University of Manitoba

Department of Physics

Yong Liu, Chinese Academy of Sciences

Anhui Institute of Optics and Fine Mechanics

Jian Ren, University of Winnipeg

Department of Applied Computer Science

Yikun Wang, Chinese Academy of Sciences

Anhui Institute of Optics and Fine Mechanics,

Kai Wang, Anhui Medical University, Anhui Province Hospital

Department of Neurology

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Published

2010-06-15

How to Cite

[1]
F. Yu, “Advanced Glycation End Products in Patients with Leukoaraiosis”, CMBES Proc., vol. 33, no. 1, Jun. 2010.

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Section

Academic