ThromboLUX - The First Routine Platelet Transfusion Quality Test

Authors

  • Elisabeth Maurer-Spurej University of British Columbia LightIntegra Technology Inc. Canadian Blood Services
  • Gyasi Bourne LightIntegra Technology Inc.
  • Paul Geyer LightIntegra Technology Inc.
  • Paul Charlebois StarFish Product Engineering
  • Gene Wey StarFish Product Engineering
  • Kenneth McCallum StarFish Product Engineering

Abstract

Prior to the ThromboLUX, no single in vitro test existed that could be used individually to evaluate the quality and effectiveness of platelet concentrates for transfusion. As hospitals cannot currently predict effective from ineffective transfusions prior to seeing patient responses, they purchase all platelet products. In North America every year over 3 million platelet transfusions are given to heart surgery, bleeding or cancer patients at a cost of at least 1.5 billion dollars. LightIntegra intends to make platelet quality testing a regular practice in blood banks around the world by making it accessible, affordable, reliable and fast.
The ThromboLUX uses the principle of dynamic light scattering (DLS) to determine the kind of particles in the platelet concentrate, how many of the particles exist, and how they respond to temperature stress. The temperature response of platelets was a breakthrough discovery and combined with state-of-the-art laser and optics technology the ThromboLUX addresses the market need to provide a safe, quick and simple diagnostic test for platelet quality and function.
Provision of the ThromboLUX results prior to transfusion, will allow hospitals to reduce costs. As fewer ineffective transfusions will occur, and thus fewer repeat transfusions, hospitals will reduce platelet costs as they will only be purchasing ‘good’ platelet concentrates. Additionally, patient care will improve as physicians will no longer have the uncertainty of unsatisfactory transfusion outcome and patients will no longer be exposed to a huge, under-recognized risk. Patient costs will also decrease due to the reduction in the length of hospital stays.
The significant cost reduction gained by eliminating the use of ineffective platelets, improved efficiency, and the correlation of the ThromboLUX test results with transfusion outcome are strong incentives for the adoption of ThromboLUX.

Downloads

Published

2010-06-15

How to Cite

[1]
E. Maurer-Spurej, G. Bourne, P. Geyer, P. Charlebois, G. Wey, and K. McCallum, “ThromboLUX - The First Routine Platelet Transfusion Quality Test”, CMBES Proc., vol. 33, no. 1, Jun. 2010.

Issue

Section

Medical Devices