Development and Performance of a Closed-Loop Propofol System

Authors

  • Samer M. Charabati Institut de Génie Biomédical, Université de Montréal, Intelligent Technology Anesthesia Group (ITAG), Dept. of Anesthesia, McGill University
  • Pierre A. Mathieu Institut de Génie Biomédical, Université de Montréal
  • Thomas M. Hemmerling Institut de Génie Biomédical, Université de Montréal, Intelligent Technology Anesthesia Group (ITAG), Dept. of Anesthesia, McGill University

Abstract

Objective: The purpose of this project is to develop a novel, expert-based closed-loop system for propofol administration using Bispectral Index (BIS).

Methods: The system is designed to process real- time BIS during general anesthesia, compare it with a target BIS and use the difference to adjust the infusion rate of propofol. A graphical user interface as well as remote control and monitoring are integrated in the system. After IRB approval and written consent, 50 patients are randomly assigned to 2 groups of equal size. After manual propofol induction, closed loop control is used to maintain anesthesia at a chosen target BIS of 45 (Closed-loop group); in the Control group, propofol is administered manually by an experienced anesthesiologist.

Results (preliminary results, n = 22): Closed-loop control was able to achieve maintenance of anesthesia for all patients. In the Closed-loop group, BIS was within ± 10% of the target significantly longer, and outside ± 30% of the target time than in the Control group (P=0.001, P=0.01, respectively).

Discussion: An expert-based closed-loop system for propofol was designed including a numeric- graphical interface. It seems to offer better control of anesthesia than manual control.

Index Terms — Closed-loop, anesthesia, BIS, propofol 

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Published

2008-06-11

How to Cite

[1]
S. M. Charabati, P. A. Mathieu, and T. M. Hemmerling, “Development and Performance of a Closed-Loop Propofol System”, CMBES Proc., vol. 31, no. 1, Jun. 2008.

Issue

Vol. 31 (2008)

Section

Academic