The Role of Oxygen in ECM remodeling

Nadia Abzan; Zoya Versey; William Willmore; Leila Mostaco-Guidolin

The Role of Oxygen in ECM remodeling

Authors

Nadia Abzan PhD Student
Zoya Versey Carleton University
William Willmore Carleton University
Leila Mostaco-Guidolin Carleton University

Keywords:

ECM remodeling, Collagen, Hydrogels, Hypoxia

Abstract

The extracellular matrix (ECM) regulates several cellular functions via different signals. The structure and composition of the ECM change in various diseases. The mechanisms of ECM alternations and the role of oxygen in ECM remodeling is poorly understood. We are establishing in vitro models that simulate the ECM microenvironment to investigate the effect of oxygen in ECM remodeling.