TY - JOUR AU - Gao, Antao AU - Mani-Varnosfaderani, Ahmad AU - Poch, Katie AU - Caceres, Silvia AU - Nick, Jerry AU - Hill, Jane PY - 2023/05/14 Y2 - 2024/03/28 TI - Volatile sputum biomarkers can monitor the response to treatment of nontuberculous mycobacteria disease: a pilot study JF - CMBES Proceedings JA - CMBES Proc. VL - 45 IS - SE - Academic DO - UR - https://proceedings.cmbes.ca/index.php/proceedings/article/view/993 SP - AB - <p><em>Nontuberculous mycobacteria</em> disease can cause severe comorbidity and high mortality. Tracking treatment response and determining treatment endpoint remains a major challenge in the clinical management of NTM disease. The current approach for monitoring treatment response requires multiple cultures and radiographic results, which is time-consuming and relatively insensitive. Here we report nine biomarkers selected by comparing paired pre-treatment (n=6) and post-treatment (n=6) sputum samples. The suggested biomarkers can distinguish the pre-treatment group from the post-treatment group. The results demonstrate that detecting volatile sputum biomarkers is a potential supplementary tool for monitoring the response to the treatment of NTM disease.</p> ER -